Panorama Test – NIPT

Description

The Panorama Test is the only NIPT that distinguishes mother’s DNA from baby’s DNA to screen for chromosomal aneuploidies and microdeletions.

The test uses unique SNP (single nucleotide polymorphism) based technology to deliver the most accurate non-invasive prenatal testing on the market. Panorama evaluates SNPs— the 1% of our DNA that makes us different from one another.

The Panorama Test is a blood-based genetic, prenatal screening test of the pregnant mother that screens for common chromosomal conditions that affect a baby’s health and can be performed as early as nine weeks gestation. Most results will be returned within 7 working days of the sample arriving in the lab.

Panorama is a safe test for both mother and the fetus because it is performed using a simple 10ml blood sample – this will need to be collected by your Midwife, GP or Private Hospital – there may be a small charge for this service.

If you live local to one of our boutiques, you can buy your test online and opt for a complimentary blood draw from our Manchester and Lancashire based boutiques at checkout. We’ll also throw in a FREE reassurance scan worth £45!

WHO SHOULD HAVE PANORAMA PRENATAL SCREEN?

The Panorama prenatal screen is designed for women of any age and ethnicity who are at least 9 weeks pregnant. It cannot currently be used by women carrying three or more babies (triplets and above), women who have used an egg donor or surrogate carrying more than one baby (twins or triplets), or those who have received a bone marrow transplant.

WHAT ARE THE BENEFITS OF HAVING THE PANORAMA PRENATAL SCREEN?

As early as nine weeks into your pregnancy, a simple blood draw can tell you if your baby is at higher risk for having Down syndrome and other common genetic conditions, as well as the sex of your baby. Non-invasive and highly accurate, Panorama identifies up to 99% of pregnancies affected with Down syndrome and has the lowest reported false positive rate of any prenatal screening test for the commonly screened chromosomal abnormalities: trisomy 21, trisomy 18, and trisomy 13.

WHY IS PANORAMA BETTER THAN THE CURRENT NHS COMBINED TEST?

Traditional screening offered during pregnancy is currently called the combined test. This is an ultrasound scan to measure the nuchal translucency (NT) and a blood test. This is much less accurate than NIPT and it only detects around 85% of babies with Down’s syndrome.

The Panorama Test has a higher detection rate (up to 99%) than the current combined test offered to pregnant women. This means that fewer pregnant women will undergo unnecessary invasive follow-up procedures such as amniocentesis or CVS which are stressful, painful and can carry a small risk of miscarriage.

Panorama can accurately detect trisomies such as; Down syndrome, Edwards syndrome and Patau syndrome. Panorama also tests for syndromes caused by sex chromosome aneuploidies and microdeletions as well as the option to know the gender of the baby.

Validated in SMART, the largest prospective NIPT study with over 20,000 participants enrolled.

More than 3 million women in more than 60 countries have chosen Panorama for genetic testing during pregnancy.

Panorama has been evaluated in 25 peer-reviewed publications and in more than 1.3 million pregnancies.

WHAT DOES THE PANORAMA TEST SCREEN FOR:

Singleton pregnancies

• Trisomy 21 (Down syndrome)
• Trisomy 18 (Edwards syndrome)
• Trisomy 13 (Patau syndrome)
• Triploidy
• Monosomy X (Turner syndrome)
• Sex chromosome trisomies*
• Microdeletions, including 22q11.2 deletion syndrome (optional)
• Sex of the baby (optional)

Twin pregnancies

• Identical or fraternal twins
• Trisomy 21 (Down syndrome)
• Trisomy 18 (Edwards syndrome)
• Trisomy 13 (Patau syndrome)
• Sex of each twin (optional)

If our screening finds that your twins are identical, Panorama can additionally screen for:

• Monosomy X (Turner syndrome)
• Sex chromosome trisomies*
• 22q11.2 deletion syndrome (optional)

Egg donor or surrogate pregnancies

• Trisomy 21 (Down syndrome)
• Trisomy 18 (Edwards syndrome)
• Trisomy 13 (Patau syndrome)
• Sex of the baby (optional)

* Reported when suspected

THE PANORAMA NIPT TEST CAN ALSO HELP CLINICIANS TRIAGE TWIN PREGNANCIES EFFECTIVELY

Panorama identified monozygotic twins with up to 99% sensitivity and specificity in a validation study.

While chorionicity can be reliably detected early in pregnancy, studies have shown that up to 19% of monochorionic pregnancies are incorrectly classified as dichorionic.

Panorama allows clinicians to align their ultrasound findings with an early and accurate zygosity determination.

Identifying a monozygotic twin pregnancy with Panorama can prompt earlier, targeted ultrasound assessments for chorionicity and associated complications.

Knowing that a twin pregnancy is dizygotic reduces healthcare providers’ and patients’ concerns about twin-to-twin transfusion syndrome (TTTS).

PANORAMA IS THE ONLY NIPT THAT TESTS FOR TRIPLOIDY

Babies with triploidy have a complete extra set of chromosomes for a total of 69 chromosomes instead of the usual 46. At 10 weeks gestation, one in 1,000 pregnancies is affected by triploidy.

It is extremely rare for these pregnancies to reach term as they typically spontaneously miscarry early in pregnancy.

Those few liveborns usually pass away within days of delivery due to heart, brain, and kidney problems. Babies with triploidy also often have birth defects affecting the extremities and face.

Carrying a baby with triploidy can increase a mother’s risk for a variety of conditions: pre-eclampsia (which can lead to seizures) and excessive bleeding after delivery. In rare instances, triploid pregnancies can persist and progress to a type of cancer called choriocarcinoma. Knowing about triploidy allows the physician to monitor the health of the mother appropriately.

• The Panorama Test is a fast and safe process
• 10ml Blood Sample from the expectant mother
• Available from 9 weeks of pregnancy
• Gender Identification available (Optional)
• Suitable for singleton and twin pregnancies*
• Suitable for IVF pregnancy
• Results available from 7 working days from the sample arriving in the lab
• Complimentary 15-minute telephone consultation with a Genetic Counsellor in the event of a high-risk result

The Panorama Test – Standard – £399

• T21 – Downs Syndrome
• T18 – Edwards
• T13 – Patau
• Monosomy X – Turners Syndrome (not for natural non identical twins, egg donors or surrogates)
• Sex Chromosome Trisomies – Klinefelter Syndrome, Triple X Syndrome & Jacob’s Syndrome
• Triploidy (not for twins, egg donors or surrogates)
• 22Q11.2 – Di George (not for natural non identical twins, egg donors or surrogates)

The Panorama Test – Full Panel (including Microdeletions) – £499

• T21 – Downs Syndrome
• T18 – Edwards
• T13 – Patau
• Monosomy X – Turners Syndrome (not for natural non identical twins, egg donors or surrogates)
• Sex Chromosome Trisomies – Klinefelter Syndrome, Triple X Syndrome & Jacob’s Syndrome
• Triploidy (not for twins, egg donors or surrogates)
• 22Q11.2 – Di George (not for natural non identical twins)
• 1p36 deletion syndrome (natural single pregnancy only)
• Cri du chat syndrome (5p-) (natural single pregnancy only)
• Angelman syndrome (natural single pregnancy only)
• Prader-willi syndrome (natural single pregnancy only)

Please see information regarding twin and IVF pregnancies above to see what tests are available.

Natera, the test provider, also offer free genetic counselling via a telephone consultation for all test results.

We always recommend that results are discussed with your Healthcare Professional

Please take the time to familiarise yourself with our NIPT FAQs before placing your order

Please click here to see Brochure

Clinical Performance Information (inc PPV Rates) can be found below:

Figure 1: Panorama trisomy 21 clinical PPVs are stable across age groups while “counting” NIPT analytical PPVs are much lower in younger women.

Figure 2: Panorama’s clinical PPVs for the common aneuploidies were comparable between average-risk and high-risk patients.